As a study coordinator, I recruit participants to a randomized clinical trial that’s evaluating experimental drugs for renal cancer. One of the individuals who met the trial’s eligibility criteria told me that he was enrolling regardless of what the informed consent document described. When I asked him if he had questions, he said, “What do I have to lose? I trust my physician to know what’s best for me.” He then signed the document. Even though I felt uncomfortable and allowed him to sign it, I wondered if I should have.