In July, the American Nurses Association (ANA) hosted its first in-person Sharps Injury (SI) Prevention Stakeholder meeting. Experts, advocates, specialists, and frontline nurses from varied backgrounds with global renown convened to discuss the state of sharps injuries and needlesticks in U.S. health care. With hepatitis C infections and associated comorbidities, including metabolic syndrome, diabetes, and coinfection with hepatitis B, HIV or multidrug resistant organisms, at an all-time high, especially among baby boomers, renewing focus and making concerted efforts to reduce sharps injuries and bloodborne and infectious disease exposures is time critical.