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Drugs today – May 2009


New alert on sharing insulin pens

The Food and Drug Administration (FDA) has issued an alert to remind healthcare providers and patients that sharing insulin pens may result in the transmission of hepatitis viruses, human immunodeficiency virus (HIV), and other blood-borne pathogens. Each insulin pen (and each insulin pen cartridge) is designed for single-patient use only and should never be shared among patients. Even if needles are changed between patients, any blood contamination of the pen reservoir could result in the transmission of blood-borne pathogens from the previous user.

The FDA has received information that insulin pens may have been shared among 2,000 or more patients in one hospital from 2007 to 2009 and among a smaller number of patients in at least one other hospital. Patients treated with insulin pens at these hospitals are being contacted and offered testing for hepatitis and HIV.

New indication for hepatitis C drugs

The FDA has approved Peg-Intron (peginterferon alfa-2b) and Rebetol (ribavirin) for patients who haven’t recovered from hepatitis C after an earlier treatment. The drugs were already approved for patients who had never taken a drug for hepatitis C. According to the manufacturer, Schering-Plough, more than 100,000 people in the United States have received at least one unsuccessful treatment for hepatitis C.

Warning on metoclopramide

Manufacturers of metoclopramide (Reglan), a drug used to treat GI disorders, must add a boxed warning to their drug labels. That’s because long-term or high-dose use of metoclopramide has been linked to tardive dyskinesia, which may include involuntary, repetitive body movements. The FDA will require manufacturers to implement a risk evaluation and mitigation strategy to ensure that patients are provided with a medication guide that discusses this risk.

Antibiotic-asthma link in children

According to a recent study, using antibiotics in children during the first year of life poses a small risk of childhood asthma. Using administrative data from 1997 to 2003, the research­ers assessed the incidence of asthma after the first 24 months of life in children who received antibiotics and children who did not receive antibiotics during the first 12 months of life. Though the risk of asthma was small, the risk increased with the number of courses of anti­biotics a child received.

Epilepsy drug can cause metabolic acidosis

Zonisamide (Zonegran), which is used as an adjunct in the treatment of partial seizures in adults with epilepsy, can cause metabolic acidosis in some patients. Those with predisposing conditions, including renal disease, severe respiratory disorders, and diarrhea, as well as those undergoing surgery, using a ketogenic diet, or taking certain other drugs, may be at greater risk. The risk of zonisamide-induced metabolic acidosis also appears higher in younger patients. The FDA is working with the makers of zonisamide to revise the product labeling.

The views and opinions expressed here are those of the author and do not necessarily reflect the opinions or recommendations of the American Nurses Association, the Editorial Advisory Board members, or the Publisher, Editors and staff of American Nurse Journal. This has not been peer reviewed.

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