Clinical TopicsFeaturesGastroenterologyPatient SafetySurgeryWorkplace Management

Putting a stop to postop nausea and vomiting


For patients recovering from surgery, the biggest obstacle isn’t pain, sore throat, or having to depend on others for care. It’s postoperative nausea and vomiting (PONV). A 2001 survey found the average patient would be willing to spend more than $100 out of pocket to avoid postoperative GI distress.
Despite anesthetic and surgical advances, the estimated incidence of PONV is as high as 30% for low-risk patients and 80% for high-risk patients. New drug therapies show promise in controlling early PONV—yet nearly half of patients may experience nausea and vomiting after discharge from ambulatory surgery units. They suffer an uncomfortable recovery and are more likely to require hospitalization.
We nurses can help change that. For starters, we can help minimize PONV by identifying high-risk patients preoperatively and implementing multimodal therapy based on risk assessment. Plus, we can teach postoperative patients and their families strategies to help them cope with the discomfort and potentially debilitating effects of PONV.

Assessing risk
PONV is more likely to follow certain types of surgeries—for instance, eye surgery; ear, nose, and throat surgery; gynecologic surgery; and gallbladder surgery. Yet the specific surgery doesn’t predict PONV.
On the other hand, having a PONV risk factor independently predicts an untoward event. Strong evidence confirms four patient-
related and three anesthesia-related risk factors. By identifying your patient’s risk factors preoperatively and using a simple risk-scoring tool, you can determine the baseline risk for PONV and help develop a prophylactic management plan. (See Determining your patient’s risk factors and risk score in pdf format available by clicking pdf icon above.)

Prophylactic interventions
A patient’s PONV risk score determines the number of prophylactic interventions required; a high risk score warrants more interventions. (Universal prophylaxis for all elective surgery patients is ineffective and thus not recommended.)
Prophylactic interventions include:
•    minimizing anesthesia factors (such as use of volatile anesthetic gases) that increase the PONV risk
•    administering prophylactic drugs
•    optimizing hydration before and during surgery.
Research also supports the use of prophylactic complementary interventions, such as P6 acupoint stimulation. In this technique, the practitioner stimulates the area between the flexor tendons and three fingerbreadths distal to the hand-wrist crease, using acupuncture needles or acupressure.
A multimodal approach to pain management, such as use of non­-steroidal anti-inflammatory drugs in conjunction with regional analgesia, also reduces the risk of PONV.

Prophylactic drugs
Antiemetic drugs act on specific receptors in the brain’s chemoreceptor trigger zone (CTZ) and the nucleus tractus solitarius (NTS)—both of which send messages to the vomiting center in the mid-brainstem. The CTZ contains dopamine, muscarinic, histamine-1 (H1), serotonin, neurokinin-1 (NK1), and opioid receptors. The NTS contains dopa­mine, serotonin, histamine, and muscarinic receptors.
For PONV prophylaxis, the patient typically receives drugs that act on several receptor types simultaneously. For a patient with a PONV risk score above 3, the anesthetist may select multiple drugs, each acting on a different receptor type, for multimodal prophylaxis. Research shows that H1-receptor blockers, NK-receptor antagonists, serotonin (5-HT3)-receptor antagonists, and muscarinic-receptor blockers are effective in PONV prophylaxis. Dexamethasone also is well established as an effective (and relatively low-cost) prophylactic antiemetic, though its exact mechanism is unknown.
Drugs that directly increase GI motility, such as metoclopramide, haven’t been shown to offer effective prophylaxis. Although it’s a dopamine-receptor blocker, metoclopramide usually is given in a dosage too low (10 mg I.V.) to affect the CTZ.
On the other hand, droperidol (also a dopamine-receptor blocker) does have prophylactic antiemetic properties. But the Food and Drug Administration requires stringent cardiac monitoring during its administration, so its use in ambulatory surgical patients isn’t practical.

Adequate hydration
Dehydration can play a role in PONV: Low blood pressure compromises intestinal perfusion and can cause GI intolerance. After consulting the anesthetist, inform healthy patients scheduled for elective procedures that they may drink clear fluids up to 2 hours before surgery (unless contraindicated). Additional supplemental I.V. fluids can help prevent PONV in high-risk patients.

Rescue treatment
Sometimes, even a patient deemed at low risk experiences PONV. And high-risk patients receiving multimodal treatment still have a 20% risk of PONV. Both groups require rescue treatment. The first priority is promoting hydration, which active vomiting can further compromise.
You can play a role in choosing a specific rescue antiemetic. Find out which prophylactic antiemetics your patient has already received; the rescue antiemetic should be one that affects different receptor sites than the drugs already given. For example, if your patient received an H1-receptor blocker before or during surgery, a 5-HT3 antagonist might be a good choice for a rescue drug. (See Prophylactic and rescue antiemetics in pdf format available by clicking download now.)

When nausea and vomiting arise after discharge
It’s bad enough when a postoperative patient experiences nausea and vomiting in the hospital, where healthcare professionals are available to provide intervention. All too often, though, nausea and vomiting are delayed until after discharge. (See Timeline for PONV and PDNV in pdf format available by clicking pdf icon above).
High-risk ambulatory surgery patients should be identified and given prophylactic antiemetics. Aprepitant (Emend), the newest antiemetic, was approved in 2007 for surgical outpatients. An NK1-receptor antagonist originally developed for chemotherapy-induced nausea, it has shown promise in surgical patients when given as a single oral dose within 3 hours of anesthesia.
Prophylactic antiemetics and adequate hydration can help ambulatory surgical patients avoid both early and late postdischarge nausea and vomiting (PDNV). Still, on follow-up assessment, many patients report PDNV and delayed PDNV. So during outpatient discharge education, teach patients and home caregivers how to manage nausea and vomiting. Provide instructions on appropriate food and fluid choices, and encourage frequent
intake of clear liquids in small amounts. Advise patients to avoid acidic fruit juices and milk-based products immediately after surgery because these can increase gastric secretions. Caution them not to drink excessive amounts of carbonated beverages, such as soft drinks, which can distend the stomach.

Recommended postop intake
“Flat” ginger ale can be helpful in easing PONV. A meta-analysis of five randomized research studies found that 1 g of ginger reduced PONV more effectively than placebo. Also, animal studies show ginger works on serotonin receptors. Recommend popsicles, apple juice, and electrolyte drinks as well.

Other nursing interventions
Many patients stop taking pain medication when they experience PDNV. This can backfire, because pain has an emetic effect. However, opioids may stimulate the vomiting center, so patients with suspected opioid-induced PDNV may need to switch to an anti-inflammatory agent. Be sure to teach your patient not to take anti-inflammatory agents, opioids, or antibiotics on an empty stomach.
Urge patients to contact the physician or surgical center if PDNV persists. (In a recent survey, fewer than 4% of ambulatory surgery patients with significant PDNV said they’d contacted a healthcare provider about the problem.) Explain that postdischarge rescue antiemetics can be prescribed for use after discharge.
Despite the relatively little research done on PONV and PDNV, we can offer nursing care consistent with the results of inpatient studies and evidence-based guidelines. With more than 65% of surgeries taking place in outpatient facilities and most patients returning home within 4 hours, PONV and PDNV affect significant numbers. With effective nursing interventions, you can help prevent this “big little problem.”

Selected references
American Society of PeriAnesthesia Nurses. Evidence-based clinical practice guideline for the prevention and/or management of PONV/PDNV algorithms. J Perianesth Nurs. 2006;21(6):374-376.
Chaiyakunapruk N, Kitikannakorn N, Nathisuwan S, et al. The efficacy of ginger for the prevention of postoperative nausea and vomiting: a meta-analysis. Am J Obstet Gynecol. 2006;194:95-99.
Fetzer S, Hand M, Bouchard P, Smith H, Jenkins M. Self-care activities for post discharge nausea and vomiting. J Perianesth Nurs. 2005;20(4):249-254.
Gan TJ, Sloan F, Dear GL. How much are patients willing to pay to avoid postoperative nausea and vomiting? Anesth Anal. 2001;92:393-400.
Golembiewski J, Tokumaru S. Pharmacological prophylaxis and management of adult postoperative/postdischarge nausea and vomiting. J Perianesth Nurs. 2006;21(6):385-397.
Odom-Forren J, Fetzer S. Moser D. Evidence-based interventions for post discharge nausea and vomiting: a review of the literature. J Perianesth Nurs. 2006;21(6):411-430.

Susan Fetzer is Associate Professor in the Department of Nursing at the University of New Hampshire in Durham.


  • I am scheduled for total knee replacement. Pain med will be hydro morphine this time. Previous ortho surgeries I could only take tolerate Tylenol 2 before the nausea made me non Compliant. Needless to say, pain was over the top. What is best anti nausea med for talking with hydromorphone? I am hoping it will actually work for the pain. This is concerning me way more than the surgery itself.

  • What food could patient use?
    Ugali,rice,chips,….or what?

  • Prevention of vomiting and postoperative stomach is to use ginger as a one thing so how ginger will be used that i mean in what form?

  • You have to be careful with those ear patches. If you wear them for more than three days, you will develop exactly what you are wearing them for. Nausea and vomiting. As your doc for 8mg Zofran meltaways. They are very effective. Good luck

    • Margaret Hammond
      January 3, 2020 10:14 am

      I have been taking zofran meltaways for a week and am still nauseous. What can I do?

  • I had 60% of my thyroid removed 7 weeks ago, and I’m still experiencing severe nausea. I’ve been using scapolime ear patches to function. I need to get off these patches, but when removed, extremely nauseated. I’m looking for a solution.

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