Statins and Parkinson’s disease

statins parkinsons disease

Use of statins is associated with a higher risk for Parkinson’s disease, according to a study in Movement Disorders

Objective
Using a large U.S. claims database (MarketScan), we investigated the controversy surrounding the role of statins in Parkinson’s disease (PD).

Statins may facilitate Parkinson’s disease: Insight gained from a large, national claims database

Methods
We performed a retrospective case-control analysis. First, we identified 2322 incident PD cases having a minimum of 2.5 years of continuous enrollment prior to earliest diagnosis code or prescription of antiparkinson medication. A total of 2322 controls were then matched individually by age, gender, and a follow-up window to explore the relationship of statin use with incident PD.

Results
Statin usage was significantly associated with PD risk, with the strongest associations being for lipophilic (odds ratio = 1.58, P < .0001) versus hydrophilic (odds ratio = 1.19, P = .25) statins, statins plus nonstatins (odds ratio = 1.95, P < .0001), and for the initial period after starting statins (<1 year odds ratio = 1.82, 1-2.5 years odds ratio = 1.75, and ≥2.5 years odds ratio = 1.37; Ptrend < .0001).

Conclusion
The use of statin (especially lipophilics) was associated with higher risk of PD, and the stronger association in initial use suggests a facilitating effect. © 2017 International Parkinson and Movement Disorder Society

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2 COMMENTS

  1. I am a 51 year old female that just found out I have Parkinson’s about a year and half, but I have been having signs of it for years, tremors, depression, body weakness. ECT. I honestly don’t think my doctor was reading the signs because of my gender and age. A few years ago I had my shoulder lock up on me and I was sent to a P.T since x-rays didn’t show any physical damage. My shaking was getting worse and I began falling. Only when my speech became so bad that it brought concern to my dentist was Parkinson’s even considered. He phoned my doctor with his concerns about my shaking and balance problems. By this time I was forgoing shots in the back of my neck for back and neck pain to which once again I was sent to a P.T (although x-rays showed no damage) I was told I had a few spurs which were most likely causing the pain. Here I was feeling like my whole body was falling apart and doctor could not find anything wrong, maybe in was all in my head? My doctor even seemed annoyed with me and things just kept progressing and I just kept it to myself, why bother going through testing and them finding nothing? Well, it was after my second P.T called my doctor about the weakness in my legs and arms, by this time I have developed a gait in my walk and I fell more frequently. Only then did my doctor send me to a specialist and it was found that I had Parkinson’s, and that I have had it for awhile. I think because I was a woman that my signs and symptoms weren’t taken seriously and therefor left untreated for so long,I was taking pramipexole dihydrochloride three times daily, I Was on carbidopa levodopa but only lasted 90 minutes then wore off.I found that none of the current medications worked effective for me.I got tired of using those medication so I decided to apply natural herbs formula that was prescribed to me by my second P.T, i purchase the herbal formula from totalcureherbsfoundation. com, There has been huge progression ever since I start the treatment plan which will last for 15 weeks usage.all the symptoms and sign has begin to disappear .

  2. One faithful day on the internet I saw some post’s about perfecthealthherbalmedicinehome,so many people was talking about their herbal medicine that they cures different kinds of deadly diseases,so i decided to give it a try ,i contacted them via their email,(perfecthealthherbalmedicine gmail com) website;(www perfecthealthherbal weebly com),so they replied me,and told me that they will cure me within 5-6 weeks ,then i purchased the herbal medicine and they sent the herbal medicine to me via courier service,which i received within 2days.so after 5 weeks of usage all my symptoms disappeared totally ,then i went for medical check-up and doctor confirmed i am totally cured and parkinson’s diseases free.so please viewers my testimony is a true life story,all thanks to perfecthealthherbalmedicinehome…

    Best Regards
    Foster Kelis

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