An 80-year-old man received a diagnosis of acute myeloid leukemia. He’s been hospitalized for a month, including an ICU stay during which he received mechanical ventilation due to acute hypoxic respiratory failure. He also developed an acute kidney injury secondary to tumor lysis syndrome, for which he required continuous renal replacement therapy and now needs intermittent hemodialysis. The patient’s oncology nurse notices that he appears confused and lethargic. He follows simple commands, but his speech is incomprehensible and he can’t answer simple questions.